Auditory startle response in cervical dystonia
Identifieur interne : 004175 ( Main/Exploration ); précédent : 004174; suivant : 004176Auditory startle response in cervical dystonia
Auteurs : Jörg Müller [Autriche] ; Markus Kofler [Autriche] ; Gregor K. Wenning [Autriche] ; Klaus Seppi [Autriche] ; Josep Valls-Solé [Espagne] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-12.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Acoustic stimulus, Adult, Aged, Auditory Perception (physiology), Botulinum Toxins, Type A (therapeutic use), Brain Stem (physiopathology), Brain stem, Dystonia, Electromyography, Electromyography (instrumentation), Female, Humans, Male, Middle Aged, Neck, Neuromuscular Agents (therapeutic use), Pathophysiology, Reflex, Startle (physiology), Startle reflex, Torticollis (drug therapy), Torticollis (physiopathology), auditory startle response, brainstem reflex, cervical dystonia, pedunculopontine nucleus (PPN).
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug therapy : Torticollis.
- instrumentation : Electromyography.
- physiology : Auditory Perception, Reflex, Startle.
- physiopathology : Brain Stem, Torticollis.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
The excitability of brainstem neurons is abnormally enhanced in patients with cervical dystonia (CD), but the extend of such abnormality is not known. We examined whether patients with CD showed abnormalities in the auditory startle response (ASR), a brainstem reflex elicited by an unexpected loud stimulus. Thirteen patients with CD were investigated 3 months after botulinum toxin treatment. Thirteen healthy volunteers served as controls. ASRs were elicited by binaural high‐intensity auditory stimuli. Reflex electromyographic (EMG) activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. We found that ASR onset latencies were similar for patients and controls. CD patients had significantly lower ASR probabilities than controls (P = 0.007). ASR area under the curve was significantly smaller in CD patients (P = 0.017). Similar to controls, patients showed a significant habituation of ASR (P < 0.001, each); however, CD patients showed a prolonged tonic or phasic EMG activity after the initial ASR that was not observed in controls. Normal latencies and recruitment pattern indicate a preserved organization of intrinsic neural pathways mediating ASR in CD. Reduced ASR probability and magnitude as well as prolonged EMG activity after the proper startle response corroborate and extend previous findings on brainstem dysfunction in CD. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10609
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-12">2003-12</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1522">1522</biblScope><biblScope unit="page" to="1526">1526</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">CD908077747990C3567804B6B95A1689771218B5</idno><idno type="DOI">10.1002/mds.10609</idno><idno type="ArticleID">MDS10609</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic stimulus</term><term>Adult</term><term>Aged</term><term>Auditory Perception (physiology)</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Brain Stem (physiopathology)</term><term>Brain stem</term><term>Dystonia</term><term>Electromyography</term><term>Electromyography (instrumentation)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neck</term><term>Neuromuscular Agents (therapeutic use)</term><term>Pathophysiology</term><term>Reflex, Startle (physiology)</term><term>Startle reflex</term><term>Torticollis (drug therapy)</term><term>Torticollis (physiopathology)</term><term>auditory startle response</term><term>brainstem reflex</term><term>cervical dystonia</term><term>pedunculopontine nucleus (PPN)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Auditory Perception</term><term>Reflex, Startle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Cou</term><term>Dystonie</term><term>Electromyographie</term><term>Physiopathologie</term><term>Réflexe sursaut</term><term>Stimulus acoustique</term><term>Tronc cérébral</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The excitability of brainstem neurons is abnormally enhanced in patients with cervical dystonia (CD), but the extend of such abnormality is not known. We examined whether patients with CD showed abnormalities in the auditory startle response (ASR), a brainstem reflex elicited by an unexpected loud stimulus. Thirteen patients with CD were investigated 3 months after botulinum toxin treatment. Thirteen healthy volunteers served as controls. ASRs were elicited by binaural high‐intensity auditory stimuli. Reflex electromyographic (EMG) activity was recorded simultaneously with surface electrodes bilaterally from masseter, orbicularis oculi, sternocleidomastoid, and biceps brachii muscles. We found that ASR onset latencies were similar for patients and controls. CD patients had significantly lower ASR probabilities than controls (P = 0.007). ASR area under the curve was significantly smaller in CD patients (P = 0.017). Similar to controls, patients showed a significant habituation of ASR (P < 0.001, each); however, CD patients showed a prolonged tonic or phasic EMG activity after the initial ASR that was not observed in controls. Normal latencies and recruitment pattern indicate a preserved organization of intrinsic neural pathways mediating ASR in CD. Reduced ASR probability and magnitude as well as prolonged EMG activity after the proper startle response corroborate and extend previous findings on brainstem dysfunction in CD. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Espagne</li></country><region><li>Catalogne</li><li>Tyrol (Land)</li></region><settlement><li>Barcelone</li><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name></noRegion><name sortKey="Kofler, Markus" sort="Kofler, Markus" uniqKey="Kofler M" first="Markus" last="Kofler">Markus Kofler</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Valls Ole, Josep" sort="Valls Ole, Josep" uniqKey="Valls Ole J" first="Josep" last="Valls-Solé">Josep Valls-Solé</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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